Micro-for-Nano (M4N) Systems for Single Molecule Sensors and Molecular Electronics

Micro-for-Nano (M4N) approach merges the innovative properties of nanomaterials for sensing at nanoscale with the reliability, low-cost and accuracy of CMOS electronics. It is the "last mile" solution for interfacing nano structures to external circuits and devices. The goal is to build a fully integrated CMOS chip with on the top the sensing structures and at the bottom the readout,elaboration and, in case, the wireless transmission circuits. An integrated System-on-Chip drives the assembly phase and sensor measurement, if properly configured by an external microcontroller unity. It is also connected to a working-station for real-time data storage, implementing an innovative portable device for nanosensing. For deposition of nano structures, or even biomolecules, on chip surface Dielectrophoresis (DEP) technique is exploited to assembly different nanosensors onto Multi-Electrode Array (MEA) of the CMOS device. The two most important applications to which the research is targeted are Single Molecule Sensors and Molecular Devices, starting from the fabrication of nanoprobes (nanogaps) up to the molecular level modeling on nanodevices, ending with the design of novel nanodevices both based on organic and biomolecules. On the spot can be considered mostly three activities:

  1. Fabrication of NanoGaps by Electromigration and related modeling;
  2. Realization of Single Biomolecule Sensors;
  3. Design and Implementation of Molecular Electronics Devices.


ERC Sector:

  • PE7_4 (Micro and nano) systems engineering
  • PE7_5 (Micro and nano) electronic, optoelectronic and photonic components
  • PE7_11 Components and systems for applications


  • Nanosensors
  • Molecular electronics
  • Lab on CMOS
  • Single Molecule Sensors

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